Vulnerable Atherosclerosis Plaque 2021 |
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Vulnerable atherosclerotic plaque – a review of current.

Atherosclerosis is a chronic, systemic, inflammatory disease of the medium and large arteries such as the coronary, carotid and peripheral arteries, and the aorta. It is currently considered a major. Vulnerable atherosclerotic plaque – a review of current concepts and advanced imaging Miloslav Spaceka, David Zemanekb, Martin Hutyraa, Martin Slukaa, Milos Taborskya Atherosclerosis is the most common cause of both carotid and coronary steno-occlusive disease. Rupture of an ath Atherosclerosis AS, especially the vulnerable AS plaque rupture-induced acute obstructive vascular disease, is a leading cause of death. Accordingly, there is a need for an effective method to draw accurate predictions about AS progression and plaque vulnerability. Herein we report on an approach to constructing a hybrid nanoparticle system.

The cardiovascular science community has pursued the quest to identify vulnerable atherosclerotic plaque in patients for decades, hoping to prevent acute coronary events. However, despite major advancements in imaging technology that allow visualization of rupture-prone plaques, clinical studies have not demonstrated improved risk prediction. recently, results of carotid atherosclerosis studies [9] suggest examining pathology of atherosclerosis noninvasively to help determine which patients would benefit from early inter-vention. Imaging could be performed to characterize carotid plaque, to risk stratify asymptomatic patients, and to provide appropriate preventative therapy. course of atherosclerosis. Vulnerable plaques have insightfully. been de fi ned as those plaques prone to becoming culprit. plaques Table 2, causing acute vascular events or death, regardless.

The Myth of the “Vulnerable Plaque” Transitioning From a Focus on Individual Lesions to Atherosclerotic Disease Burden for Coronary Artery Disease Risk Assessment Armin Arbab-Zadeh, MD, PHD, Valentin Fuster, MD, PHDy ABSTRACT The cardiovascular science community has pursued the quest to identify vulnerable atherosclerotic plaque in. Erosion-Prone Plaques. Vulnerable plaques of the erosion-prone type are heterogeneous and defined only by their fate thrombosis, mostly mural Figure 47.2; Schaar et al., 2004; Virmani et al., 2005. The surface endothelium is missing, but whether it vanished before or after thrombosis remains unknown. Life style changes and improved medical therapy have decreased cardiovascular mortality in many countries over the last decades. This has been accompanied by changes in disease characteristics including more non-ST segment elevation myocardial infraction and less vulnerable plaques as assessed by histological analysis of surgical specimens.

Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque. Initially, there are generally no symptoms. When severe, it can result in coronary artery disease, stroke, peripheral artery disease, or kidney problems, depending on which arteries are affected. Abstract. Atherosclerosis involving the carotid arteries has a high prevalence in the population worldwide. This condition is significant because accidents of the carotid artery plaque are associated with the development of cerebrovascular events. Inflammation and calcification concomitantly drive atherosclerotic plaque progression and rupture and are the compelling targets for identifying plaque vulnerability. However, current imaging modalities for vulnerable atherosclerotic plaques are often limited by inadequate specificity and sensitivity. Here, we show that natural H-ferritin. These findings were verified in the single-center VIVA VH-IVUS in Vulnerable Atherosclerosis study, in which the strongest RF-IVUS lesion predictors of nonculprit lesion–related adverse events at mean 1.7-year follow-up were a large plaque burden and RF-TCFA. Die instabile Plaque wird auch als vulnerable Plaque bezeichnet. Im Gegensatz zur stabilen Plaque besitzt sie nur eine dünne Faserkappe über dem lipidhaltigem Gewebeareal. Diese dünne Kappe kann aufreißen, was als Plaqueruptur bezeichnet wird. Instabile Plaque findet sich meist in arteriellen Blutgefäßen, deren Stenosegrad unter 50% liegt.

However, identification of the vulnerable plaque is not yet ready for clinical application, as the prognostic significance of a vulnerable plaque phenotype is poor, and a clinical benefit from interventions targeting vulnerable plaques is yet to be proven. Therefore, a better identification process needs to be implemented that can increase the.

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